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TEM5 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550672

Catalog No. PA550672


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Description

Description

The antibody detects endogenous levels of total GPR124 / TEM5 protein.

Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
Specifications

Specifications

TEM5
Polyclonal
Unconjugated
ADGRA2
Liquid
ADGRA2
Synthetic peptide corresponding to a region derived from internal residues of human G protein-coupled receptor 124
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
2.9 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q96PE1, Q91ZV8
DKFZp434C211, DKFZp434J0911, FLJ14390, KIAA1531, TEM5
Rabbit
IgG
100 μL
-20°C
Primary
25960, 78560
Documents
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