Invitrogen™ GPS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530953

Catalog No. PIPA530953

Description

Recommended positive controls: A431, HeLa. Predicted reactivity: Mouse (98%), Rat (98%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.

Specifications

• Antigen: GPS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPS2
• Gene Alias: AI505953; AMF-1; G protein pathway suppressor 2; GPS2; GPS-2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2874
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.2 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q13227
• Gene Symbols: GPS2
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 253 of Human GPS2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov