GPX1 Polyclonal Antibody, Invitrogen™

Sheep Polyclonal Antibody

Supplier:  Thermo Scientific PA118279

Catalog No. 01-670-532

Description

Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.

Order Info

Not available outside US

Specifications

• Antigen: GPX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GPX1
• Gene Alias: AI195024; AL033363; Cellular glutathione peroxidase; CGPx; cytosolic glutathione peroxidase; glutathione peroxidase; glutathione peroxidase 1; Gpx; Gpx1; GPx-1; GPXD; GSHPx; GSHPX1; GSHPx-1; HGNC:4553; MGC14399; MGC88245; OTTHUMP00000210766; Selenium-dependent glutathione peroxidase 1
• Host Species: Sheep
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Concentration: Conc. Not Determined
• Formulation: whole serum with no preservative
• Gene Accession No.: P04041, P07203
• Gene Symbols: GPX1
• Immunogen: Synthetic peptide corresponding to residues R(175) R Y S R R F Q T I D I E P D I E A L L(194) of human glutathione peroxidase 1 ( GPx-1).
• Regulatory Status: RUO
• Gene ID (Entrez): 24404, 2876
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov