Epredia™ Lab Vision™ Granzyme B Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with Epredia™ Granzyme B Ab-1, Mouse Monoclonal Antibody.

Supplier:  Epredia™ MS1157RQ

Catalog No. MS1157RQ

Description

Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified. One of these, human granzyme B, is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity. Exocytosis of granzyme-containing granules in the cytoplasm of the target cell leads to the induction of DNA fragmentation and apoptosis.

Host Species: Mouse

Clone: GZB01

Isotype: IgG2a

Species Reactivity: Human. Others not known.

Epitope: N-terminal

Immunogen: Recombinant protein encoding the N-terminus of the mature granzyme B

Molecular Weight: 32 kDa

Positive Control: Hodgkin's lymphoma, Tonsil

Cellular Localization: Granular cytoplasmic

Recommended for:

• Immunohistochemistry (Formalin/paraffin only)

Specifications

• Antigen: Granzyme B Ab-1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: Recombinant protein encoding the N-terminus of the mature granzyme B
• Regulatory Status: IVD
• Primary or Secondary: Primary

• Applications: Immunohistochemistry (Paraffin)
• Clone: GZB01
• Host Species: Mouse
• Quantity: 12 mL
• Research Discipline: Apoptosis
• Form: Ready-to-Use