GRAP2 Mouse anti-Human, Clone: OTI1G2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525548
DescriptionThe Src homology 3 (SH3) region is a small protein domain of approximately 60 amino acids present in a large group of proteins. In general, it exists in association with catalytic domains, as in the nonreceptor protein-tyrosine kinases and phospholipase C-gamma, within structural proteins, such as spectrin or myosin, and in small adapter proteins, such as Crk and GRB2. SH3 domains are often accompanied by SH2 domains of 100 amino acids that bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. Deletion or mutation of SH3 domains generally activates the transforming potential of nonreceptor tyrosine kinases, suggesting that SH3 mediates negative regulation of an intrinsic transforming activity. Gads is an adapter proteins that contains both SH2 and SH3 domains. Gads binds to tyrosine-phosphorylated proteins, such as Shc, and functions to couple these proteins to downstream effectors.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|RP3-370M22.1, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB-2-like protein, GRB2-related adapter protein 2, GRB2-related protein with insert domain, SH3-SH2-SH3 adapter Mona, SH3-SH2-SH3 adaptor molecule, adapter protein GRID, grf-40, grf40 adapter protein, growth factor receptor-binding protein, growth factor receptor-bound protein 2-related adaptor protein 2, hematopoietic cell-associated adapter protein GrpL, hematopoietic cell-associated adaptor protein GRPL|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of GRAP2 produced in HEK293T cell|
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