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Thermo Scientific™ Lab Vision™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.

Manufacturer:  Thermo Scientific™ MS1457R1

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Catalog No. MS1457R1

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody.

Grb2 protein contains one SH2 domain flanked on both sides by an SH3 domain. Ab-1 binds to the junction between the amino terminal SH3 domain and the SH2 domain of Grb2. Reactivity with Grb2 deletion mutants suggests that its epitope maps between aa 54-62. In response to EGF, Grb2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The Grb2-Sos complex then binds the EGF-receptor. These interactions play a critical role in the activation of the p21ras signalling pathway.

Host Species: Mouse

Clone: 2GB04 (C1.4)

Isotype: IgG1/κ

Species Reactivity: Human, Cow, Mouse, Rat and Xenopus. Others not known.

Epitope: aa 54-62

Immunogen: Purified recombinant human Grb2 protein

Molecular Weight: 24-25 kDa

Positive Control: HeLa cells, Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO

General References:

1. Schlessinger J. Current Opinion in Genetics and Development, 1994 Feb, 4(1):25-30.

2. Boulikas T. Critical Reviews in Eukaryotic Gene Expression, 1995, 5(1):1-77.

3. Chardin P et al. Febs Letters, 1995 Aug 1, 369(1):47-51.

4. Downward J. Febs Letters, 1994 Jan 31, 338(2):113-7.

b>General References:

1. Schlessinger J. Current Opinion in Genetics and Development, 1994 Feb, 4(1):25-30.

2. Boulikas T. Critical Reviews in Eukaryotic Gene Expression, 1995, 5(1):1-77.

3. Chardin P et al. Febs Letters, 1995 Aug 1, 369(1):47-51.

4. Downward J. Febs Letters, 1994 Jan 31, 338(2):113-7.

Specifications

Specifications

Grb2/sem5/ASH Signaling Protein Ab-4
Monoclonal
Unconjugated
Prediluted
Purified recombinant human Grb2 protein
1mL
Signal Transduction
Primary
Bovine, Human, Murine, Rat, Xenopus
Immunofluorescence, Immunohistochemistry (Paraffin)
2GB04; same as C1.4
Ready-to-use for IHC (UVLP)
Murine
IgG2a, κ
RUO
Primary
Monoclonal
SDS
Documents
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