GRB7 Mouse anti-Human, Clone: OTI15E7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527118
DescriptionMany growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus. GRB7 maps to the region on mouse chromosome 11 containing the Neu gene. This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer. Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|B47; Epidermal growth factor receptor GRB 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7; GRB7_HUMAN; Growth factor receptor bound protein 7; Growth factor receptor-bound protein 7;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Full length human recombit protein of GRB7 produced in E.coli|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok