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GRB7 Mouse anti-Human, Clone: OTI6H2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527117

Catalog No. PIMA527117


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Description

Description

Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus. GRB7 maps to the region on mouse chromosome 11 containing the Neu gene. This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer. Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185.
Specifications

Specifications

GRB7
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q14451
B47; Epidermal growth factor receptor GRB 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7; GRB7_HUMAN; Growth factor receptor bound protein 7; Growth factor receptor-bound protein 7;
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2886
Immunohistochemistry (Paraffin), Western Blot
OTI6H2
Unconjugated
GRB7
Liquid
GRB7
Full length human recombit protein of GRB7 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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