GRM1 Mouse anti-Human, Clone:5E12D8, Abnova
Mouse monoclonal antibody raised against partial recombinant human GRM1.
Manufacturer: Abnova Corporation MAB17943
DescriptionL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq]
|glutamate receptor, metabotropic 1|
|In PBS (0.05% sodium azide)|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|ELISA, Western Blot|
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.
|GPRC1A, GRM1A, MGLUR1, MGLUR1A, mGlu1|
|Recombinant protein corresponding to amino acids 387-486 of human GRM1.|