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GRM8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 182241AP150UL

Encompass_Preferred

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Catalog No. 50-173-2057


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Description

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Specifications

Specifications

GRM8
Polyclonal
Unconjugated
GRM8
GLUR8, GPRC1H, GRM8, mGlu8, MGLUR8
Rabbit
Antigen Affinity Chromatography
RUO
14823, 2918, 60590
-20°C
Liquid
Immunohistochemistry (Paraffin)
0.37 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O00222, P47743, P70579
Grm8
GRM8 Fusion Protein Ag13011
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
SDS
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