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Cell Signaling TechnologySupplier Diversity Partner Human Transforming Growth Factor beta-3 (hTGF-beta-3) 10 ug DFS Item

Manufacturer:  Cell Signaling TechnologySupplier Diversity Partner 8425LF

8425LF , TGF-β3 can induce cell proliferation and angiogenesis, and can promote some immune events while inhibiting others (1-3). TGF-β3 is produced by chondrocytes, glial cells, astrocytes and some cancer cells (3,4). TGF-β3 binds to TβRII homodimer, which then complexes with TβRI homodimer (1,5). The oligomeric receptor complex phosphorylates subsets of SMAD proteins that then act to induce or suppress target genes (1,5). Based on knock-out studies in mice, TGF-β3 is critical for lung and palate development (6).

Catalog No. 50-194-800

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