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Tocris Bioscience™ GS 143
β-TrCP1 ligase inhibitor
Supplier: Tocris Bioscience™ 5636/50
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Description
GS 143 is a β-TrCP1 ligase inhibitor. Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.Specifications
4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid | |
50 mg | |
C28H19FN2O4 | |
>98% |
916232-21-8 | |
Ubiquitin Ligase (E3) Inhibitors | |
466.46 |
Safety and Handling
Recommended Storage : Store at 4°C
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