Tocris GSK 137647
Potent and selective FFA4 (GPR120) agonist
Manufacturer: Tocris 5257/10
DescriptionPotent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614 (Cat. No. 5256).
- Chemical Name: 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
- Formula: C16H19NO3S
- CAS Number: 349085-82-1
- Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
- Purity: >99
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