Tocris™ GSK 1562590 hydrochloride

High affinity, selective urotensin II (UT) receptor antagonist

Manufacturer: Tocris™ 5110/10

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Catalog No. 51-101-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type GSK 1562590 hydrochloride
    Inhibitors GSK 1562590 hydrochloride
    Purity >98
    Molecular Weight 617.95
    Quantity 10mg

    High affinity and selective urotensin II (UT) receptor antagonist (pKi values are 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors respectively). Exhibits selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters. Supresses human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitro and ex vivo. Inhibits the hU-II-induced increase in mean blood pressure in vivo. Orally active.

    • Chemical Name: N-[(1R)-1-[3'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-4H-1,4-benzoxazine-4-acetamide hydrochloride
    • Formula: C30H30Cl2N4O4.HCl
    • CAS Number: 1003878-07-6
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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