Tocris™ GSK 1838705

Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)

Manufacturer: Tocris™ 5111/50

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Catalog No. 51-115-0

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For Research Use Only


    Product Type GSK 1838705
    Inhibitors GSK 1838705
    Purity >98
    Molecular Weight 532.57
    Quantity 50mg

    Potent insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) inhibitor (IC50 values are 1.6 and 2 nM, respectively). Also inhibits anaplastic lymphoma kinase (ALK) (IC50 = 0.5nM). Displays > 800-fold selectivity for IR, IGFR1 and ALK over a panel of 44 kinases including JNK. Blocks proliferation of cancer cell lines in vitro, and causes complete regression of ALK-dependent tumors in vivo. Orally bioavailable.

    • Chemical Name: 2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide
    • Formula: C27H29FN8O3
    • CAS Number: 1116235-97-2
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

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