Tocris™ GSK 2193874

Potent and selective TRPV4 inhibitor; orally active

Manufacturer: Tocris™ 5106/50

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Catalog No. 51-065-0

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For Research Use Only


    Product Type GSK 2193874
    Inhibitors GSK 2193874
    Molecular Weight 691.62
    Quantity 50mg

    Potent and selectiveTRPV4 inhibitor (IC50 values are 2 and 40nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ~200 human receptors, channels and enzymes. Orally active.

    • Chemical Name: 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
    • Formula: C37H38BrF3N4O
    • CAS Number: 1336960-13-4
    • Solubility: Soluble to 20mM in 1eq. HCl and to 50mM in DMSO

  • Description & Specifications

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