Tocris GSK 2193874
Potent and selective TRPV4 inhibitor; orally active
Manufacturer: Tocris 5106/50
DescriptionPotent and selectiveTRPV4 inhibitor (IC50 values are 2 and 40nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ~200 human receptors, channels and enzymes. Orally active.
- Chemical Name: 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
- Formula: C37H38BrF3N4O
- CAS Number: 1336960-13-4
- Solubility: Soluble to 20mM in 1eq. HCl and to 50mM in DMSO