Tocris GSK 4112
Selective Rev-Erbalpha agonist
Manufacturer: Tocris 3663/10
DescriptionSelective Rev-Erbα agonist (EC50 = 250nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.
- Chemical Name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
- Formula: C18H21ClN2O4S
- CAS Number: 1216744-19-2
- Solubility: Soluble to 25mM in DMSO
- Purity: >98
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