Tocris GSK 429286
Selective Rho-kinase (ROCK) inhibitor
Manufacturer: Tocris 3726/50
DescriptionSelective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.
- Chemical Name: 4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide
- Formula: C21H16F4N4O2
- CAS Number: 864082-47-3
- Solubility: Soluble to 100mM in DMSO and to 25mM in ethanol
- Purity: >97
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