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  5. GSK J4, Tocris Bioscience™

GSK J4, Tocris Bioscience™

Catalog No. p-4817496
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Histone KDM inhibitor; cell permeable

Histone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable. Ethyl ester derivative of GSK J1 .

Negative Control also available.

Chemical Identifiers

CAS 1373423-53-0
Molecular Formula C24H27N5O2
Molecular Weight (g/mol) 417.513
InChI Key WBKCKEHGXNWYMO-UHFFFAOYSA-N
Synonym gsk-j4, gsk j4, ethyl 3-6-4,5-dihydro-1h-benzo d azepin-3 2h-yl-2-pyridin-2-yl pyrimidin-4-yl amino propanoate, ethyl 3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3-benzazepin-3-yl pyrimidin-4-yl amino propanoate, gskj4, gsk-j hplc, ethyl 3-2-pyridin-2-yl-6-1,2,4,5-tetrahydro-3h-benzo d azepin-3-yl pyrimidin-4-yl amino propanoate, ethyl 3-2-pyridin-2-yl-6-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl pyrimidin-4-yl amino propanoate, n-2-2-pyridinyl-6-1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl-4-pyrimidinyl-?-alanine ethyl ester, n-2-2-pyridinyl-6-1,2,4,5-tetrahydro-3h-3-benzazepin-3-yl-4-pyrimidinyl-beta-alanine ethyl ester
PubChem CID 71729975
IUPAC Name ethyl 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate
SMILES CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4

Specifications

Formula Weight 417.5
Percent Purity >99%
Quantity 10 mg
Chemical Name or Material GSK J4

Safety and Handling

Recommended Storage Store at Room Temperature
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