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Medchemexpress LLC GSK2334470 | 1227911-45-6 | 99.8% | 462.59 g/mol | 100 MG
Supplier: Medchemexpress LLC HY14981100MG
GSK2334470 is a highly specific and potent inhibitor of PDK1, exhibiting an IC50 of 10 nM. It demonstrates high selectivity, as it does not suppress the activity of 93 other protein kinases, including 13 AGC-kinases closely related to PDK1, even at concentrations 500-fold higher. In cellular studies, it effectively ablates T-loop residue phosphorylation and the activation of SGK isoforms and S6K1. In vivo, it has shown efficacy in delaying the development and inhibiting metastasis of melanoma.
- Highly specific and potent PDK1 inhibitor
- Demonstrates high selectivity, not affecting 93 other protein kinases
- Ablates T-loop residue phosphorylation and SGK/S6K1 activation
- Induces higher G0-G1 ratio in LAN-1-MK cells
- Inhibits melanoma development and metastasis in vivo
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