GSK3B Monoclonal Antibody (21A), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA17621

Catalog No. 01-670-355

Description

MA1-7621 detects GSK3 Beta from human, rat, and Xenopus laevis samples. MA1-7621 has been successfully used in ELISA, Western blot, Flow cytometry, Immunoprecipitation and Immunohistochemistry procedures. The MA1-7621 immunogen is a purified recombinant Xenopus laevis protein. Store at 4oC short term. For extended storage, keep at -80oC.

GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.

Specifications

• Antigen: GSK3B
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.01% sodium azide; pH 7.2
• Gene Accession No.: P18266, P49841, Q91757
• Gene Symbols: GSK3B, gsk3b.L
• Immunogen: Purified recombinant Xenopus laevis protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat, X. laevis
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
• Clone: 21A
• Conjugate: Unconjugated
• Gene: GSK3B
• Gene Alias: 7330414F15Rik; 8430431H08Rik; C86142; EC 2.7.11.26; FA; Factor A; fb68h05; fk80d11; glycogen synthase kinase 3; glycogen synthase kinase 3 beta; glycogen synthase kinase 3 beta L homeolog; glycogen synthase kinase 3 beta variant 1; glycogen synthase kinase 3 beta variant 2; glycogen synthase kinase 3 beta variant 3; glycogen synthase kinase 3 beta variant 4; glycogen synthase kinase 3 beta variant 5; glycogen synthase kinase 3 beta, genome duplicate a; glycogen synthase kinase-3 beta; glycogen synthase kinase-3 beta splice variant X1; glycogen synthase kinase-3 beta splice variant X2; glycogen synthase kinase-3 beta splice variant X3; GSK 3 beta; GSK 3B; gsk3; GSK-3; GSK3 beta; GSK-3 beta; GSK-3 beta GSK3B; GSK-3[b]; Gsk3b; GSK-3b; gsk3b.L; gsk3ba; gsk3beta; GSK-3beta; gsk3-beta; GSK3beta isoform; intracellular kinase; pp37; serine/threonine-protein kinase GSK3B; wu:fb68h05; wu:fk80d11; XELAEV_180112401mg; xgsk-3; Xgsk-3 protein
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 2932, 399097, 84027
• Content And Storage: 4°C short term, -80°C long term
• Form: Liquid