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GSTM2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551324

Catalog No. PA551324


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Description

Description

The antibody detects endogenous levels of total GSTM2 protein.

At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. GSTM2 is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual ft.s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
Specifications

Specifications

GSTM2
Polyclonal
Unconjugated
GSTM2
Liquid
GSTM2
Full length fusion protein of human GSTM2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
0.9 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
P28161, P15626
GST4, GSTM, GTHMUS, GSTM2-2
Rabbit
IgG
100 μL
-20°C
Primary
14863, 2946
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