GUCY1B3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 190111AP
DescriptionGuanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|O54865, P20595, Q02153|
|GC S beta 1, GC SB3, GCS beta 1, GCS beta 3, GUC1B3, GUCB3, GUCSB3, GUCY1B1, GUCY1B3|
|25202, 2983, 54195|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|GUCY1B3 Fusion Protein Ag5196|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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