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GUK1 Mouse anti-Human, Clone: OTI1D7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525487

Catalog No. PIMA525487


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Description

Description

Guanylate kinase (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus. Proteins containing one or more copies of the DHR domain, an SH3 domain as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologs) and include Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junction protein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); vertebrate 55 kD erythrocyte membrane protein (p55); C. elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However these proteins retain the residues known, in GK, to be involved in the binding of MP.
Specifications

Specifications

GUK1
Monoclonal
0.33 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q16774
RP11-520H14.2, GMK, ATP:GMP phosphotransferase, GMP kinase, guanylate kinase
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2987
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
OTI1D7
Unconjugated
GUK1
Liquid
GUK1
Full length human recombit protein of GUK1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
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