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H-2Db Mouse anti-Mouse, FITC, Clone: 27-11-13S, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen A15446

Catalog No. 50-113-7054


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Description

Description

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Specifications

Specifications

H-2Db
Monoclonal
0.5 mg/mL
PBS with 0.1% sodium azide
P14426
H2LD, H-2 class I histocompatibility antigen L-D alpha chain, H2L
Mouse
IgG2a, kappa
100 μg
4° C
Primary
14964
Flow Cytometry
27-11-13S
FITC
H2-D1
Liquid
H2-D1
mouse H-2Db
Purified
RUO
Antibody
Monoclonal
Mouse
Documents
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