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CD148 Hamster anti-Mouse, PE, Clone: 8A-1, BD

Hamster Monoclonal Antibody

Manufacturer:  BD Biosciences 565747

Catalog No. BDB565747


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Description

Description

The 8A-1 monoclonal antibody specifically binds to CD148, which is also known as Protein tyrosine phosphatase receptor type J (Ptprj), Receptor-type tyrosine-protein phosphatase eta (R-PTP-eta, PTP η ), or Density-enhanced phosphatase-1 (DEP-1). CD148 is a receptor-like tyrosine phosphatase that plays important roles in regulating cell growth, proliferation, differentiation, adhesion, and migration. It is expressed on a wide variety of cell types including epithelial cells, endothelial cells, and fibroblasts. For cells of hemopoietic origin, it is variably expressed on macrophages, neutrophils, dendritic cells, and on developing and mature B cells. CD148 is expressed on platelets and can regulate platelet activation. Although expressed at low levels on thymocytes and mature T cells, its expression is upregulated upon T cell receptor (TCR)-mediated stimulation and may play a role in regulating TCR signaling. CD148, along with CD45, are critical protein tyrosine phosphatases for regulating Src family kinase signaling networks in immune cells.

Specifications

Specifications

CD148
8A-1
PE
Aqueous buffered solution containing ≤0.09% sodium azide.
Hamster
IgG1
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
Ptprj; R-PTP-J; BET; Byp; DEP-1; PTPbeta2; Ptpb2; R-PTP-eta; Scc-1; Scc1
Affinity Purified
Mouse CD148 Transfected Cell Line
Affinity Chromatography
RUO
Primary
Murine
Documents
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