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CD272 Hamster anti-Mouse, Brilliant Violet 650, Clone: HMBT-6B2, BD Optibuild™

Hamster Monoclonal Antibody

Manufacturer:  BD Biosciences 740640

Catalog No. BDB740640

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The HMBT-6B2 monoclonal antibody specifically binds to CD272 which is also known as B- and T-lymphocyte attenuator (BTLA). CD272 is a type 1 transmembrane glycoprotein and a member of the Ig superfamily. CD272 is variably expressed on developing and mature T and B lymphocytes, NKT cells, NK cells, macrophages and dendritic cells. CD272 expression is upregulated by activated T cells including Th1, Th2, and T follicular helper cells and by anergic T cells. CD272 is structurally similar to CD152/CTLA-4 and CD279/PD-1 and functions as a coinhibitory receptor for B and T cell responses. Herpesvirus entry mediator (HVEM), also known as CD270 and LIGHT-R, has been identified as a ligand for CD272. The crosslinking of CD272 by HVEM inhibits T-cell proliferation and cytokine production.

The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 650-nm. BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors. However, the spillover can be corrected through compensation as with any other dye combination.



Brilliant Violet 650
Aqueous buffered solution containing ≤0.09% sodium azide.
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Flow Cytometry
Btla; B and T lymphocyte attenuator; B- and T-lymphocyte-associated protein
Affinity Purified
Mouse CD272
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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