CD61 Hamster anti-Mouse, Brilliant Violet 786, Clone: 2C9.G2, BD Optibuild
Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 740867
The 2C9.G2 monoclonal antibody specifically binds to the integrin β 3 chain (CD61), which associates with the integrin α v chain (CD51) to form the vitronectin receptor and with the α IIb chain (CD41) to form the gpIIb/IIIa complex. Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is also mediated by the binding of α v β 3 integrin or vitronectin receptor to CD31 (PECAM-1). In addition, interaction of the α v β
The antibody was conjugated to BD Horizon BV786 which is part of the BD Horizon Brilliant Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 786-nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy7-like dyes (eg, 780/60-nm filter).
|Brilliant Violet 786|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Itgb3; Integrin beta-3; INGRB3; Platelet glycoprotein IIIa; GP3A; GPIIIa|
|Mouse T-cell Hybridoma 2B4 Vitronectin Receptor|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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