KLRG1 Hamster anti-Mouse, Brilliant Violet 510, Clone: 2F1, BD Optibuild
Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 740156
The 2F1 monoclonal antibody specifically binds to KLRG1 ( K iller cell L ectin-like R eceptor mmunoreceptor T yrosine-based I nhibitory M otif); its ligand has not been identified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Crosslinking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++ mobiliza tion and cytotoxic responses (but not IFN-γproduction) by CD8+ T cells and inhibits IFN-γand TNF production and redirected lysis by NK cells.
The antibody was conjugated to BD Horizon BV510 which is part of the BD Horizon Brilliant Violet family of dyes. With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser.
|Brilliant Violet 510|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA; 2F1 Ag|
|A-LAK from C57BL/6 mice|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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