KLRG1 Hamster anti-Mouse, Brilliant Violet 650, Clone: 2F1, BD Optibuild™
Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 740553
The 2F1 monoclonal antibody specifically binds to KLRG1 ( K iller cell L ectin-like R eceptor mmunoreceptor T yrosine-based I nhibitory M otif); its ligand has not been identified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Crosslinking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++ mobiliza tion and cytotoxic responses (but not IFN-γproduction) by CD8+ T cells and inhibits IFN-γand TNF production and redirected lysis by NK cells.
|Brilliant Violet 650|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA; 2F1 Ag|
|A-LAK from C57BL/6 mice|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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