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KLRG1 Hamster anti-Mouse, Brilliant Violet 650, Clone: 2F1, BD Optibuild™

Hamster Monoclonal Antibody

Manufacturer:  BD Biosciences 740553

Catalog No. BDB740553


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Description

Description

The 2F1 monoclonal antibody specifically binds to KLRG1 ( K iller cell L ectin-like R eceptor mmunoreceptor T yrosine-based I nhibitory M otif); its ligand has not been identified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Crosslinking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++ mobiliza tion and cytotoxic responses (but not IFN-γproduction) by CD8+ T cells and inhibits IFN-γand TNF production and redirected lysis by NK cells.

Specifications

Specifications

KLRG1
2F1
Brilliant Violet 650
Aqueous buffered solution containing ≤0.09% sodium azide.
Hamster
IgG2, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA; 2F1 Ag
Affinity Purified
A-LAK from C57BL/6 mice
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Murine
SDS
Documents
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