Invitrogen™ Haptoglobin alpha Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142826

Catalog No. PIPA5142826

Description

Additional Information: This antibody is expected to recognize both reported isoforms (NP_005134.1; NP_001119574.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. [PMID: 21248165]. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. [PMID: 21248165].

Specifications

• Antigen: Haptoglobin alpha
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HP
• Gene Symbols: HP
• Immunogen: Peptide with sequence QCKNYYKLRTEGD (aa 51-63).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P00738
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 3240
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

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