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HAS1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550674

Catalog No. PA550674


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Description

Description

The antibody detects endogenous levels of total HAS1 protein.

Hyaluronic acid is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluro synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes.
Specifications

Specifications

HAS1
Polyclonal
Unconjugated
HAS1
Liquid
HAS1
Synthetic peptide corresponding to a region derived from internal residues of human hyaluro synthase 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
2.7 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q92839, Q61647
HAS
Rabbit
IgG
100 μL
-20°C
Primary
15116, 3036
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