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HAS1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 152291AP

Catalog No. 50-173-0082


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Description

Description

Hyaluronic acid is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluro synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes.
Specifications

Specifications

HAS1
0.18 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q61647, Q92839
HA synthase 1, HAS, HAS1, HuHAS1, hyaluro synthase 1, Hyaluronate synthase 1, Hyaluronic acid synthase 1
Rabbit
IgG
150 μL
-20°C
Primary
15116, 282821, 3036
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
HAS1
Liquid
Has1
HAS1 Fusion Protein Ag4901
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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