HAVCR2 Mouse anti-Human, Clone: OTI1D6, liquid, TrueMAB™
Mouse Monoclonal Antibody
Manufacturer: OriGene TA812506
DescriptionTIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Full length human recombit protein of human HAVCR2 produced in HEK293T cell.|
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