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HAVCR2 Mouse anti-Human, Clone: OTI1D6, liquid, TrueMAB™

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA812506

Encompass_Preferred

Catalog No. 50-168-4573


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Description

Description

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Specifications

Specifications

HAVCR2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q8TDQ0
CD366, HAVcr-2, KIM-3, TIM3, TIMD-3, TIMD3, Tim-3
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
84868
Flow Cytometry, Western Blot
OTI1D6
Unconjugated
HAVCR2
Liquid
HAVCR2
Full length human recombit protein of human HAVCR2 produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
SDS
Documents
Product Certifications
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