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HBVgp3 Mouse anti-Virus, Clone:, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524712

Catalog No. PIMA524712


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Description

Description

Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with host factors.; Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
Specifications

Specifications

HBVgp3
Monoclonal
Unconjugated
HBx
HBx
synthetic peptide directed towards the middle region of human HBVgp3
Protein A
RUO
Antibody
Monoclonal
Virus
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
Liquid
Mouse
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
944566
Documents
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