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HCN1 Mouse anti-Human, Mouse, Rat, Clone: S70-28, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527589

Catalog No. PIMA527589


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Description

Description

Hyperpolarization-activated cation channels of the HCN gene family such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
Specifications

Specifications

HCN1
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
O60741, O88704, Q9JKB0
BCNG-1, BCNG1, Brain cyclic nucleotide gated channel 1, Brain cyclic nucleotide-gated channel 1, HAC2, HCN1, HCN1_HUMAN, Hyperpolarization activated cyclic nucleotide gated potassium channel 1, Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Mouse
IgG1
100 μg
-20°C
Primary
15165, 348980, 84390
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
S70-28
Unconjugated
HCN1
Liquid
HCN1
Fusion protein amino acids 778-910 (C terminus) of rat HCN1
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
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