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HCN2 Mouse anti-Human, Mouse, Rat, Clone: S71-37, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527718

Catalog No. PIMA527718


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Description

Description

Hyperpolarization-activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
Specifications

Specifications

HCN2
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
O88703, Q9JKA9, Q9UL51
BCNG2, HAC1, brain cyclic nucleotide gated channel 2, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
Mouse
IgG1
100 μg
-20°C
Primary
114244, 15166, 610
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
S71-37
Unconjugated
HCN2
Liquid
Hcn2
Fusion protein amino acids 761-863 of rat HCN2
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
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