HDAC4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 161651AP
This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human HDAC4.Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P56524, Q6NZM9, Q99P99|
|HA6116, HD4, HDAC A, HDAC4, HDACA, histone deacetylase 4, KIAA0288|
|208727, 363287, 9759|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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