HDAC8 Monoclonal Antibody (OTI5F7), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA809654

Catalog No. 50-168-2935

Description

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

Specifications

• Antigen: HDAC8
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9BY41
• Gene Symbols: HDAC8
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-243 of human HDAC8 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI5F7
• Conjugate: Unconjugated
• Gene: HDAC8
• Gene Alias: CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55869
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid