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HDAC9 Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Supplier: Active Motif 39793
Description
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.Specifications
HDAC9 | |
Polyclonal | |
Unconjugated | |
Hdac9 | |
AV022454; D030072B18Rik; DKFZp779K1053; HD7; HD7b; HD9; HDAC; HDAC7; Hdac7b; HDAC9; HDAC9B; HDAC9FL; Hdrp; histone deacetylase 4/5-related protein; Histone deacetylase 7B; Histone deacetylase 9; Histone deacetylase-related protein; KIAA0744; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR; Mitr; mKIAA0744; RGD1310748; RGD1563092; TWIST | |
Rabbit | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Western Blot | |
Conc. Not Determined | |
whole serum with 30% glycerol and 0.035% sodium azide; pH | |
Q9UKV0 | |
Hdac9 | |
This HDAC9 antibody was raised against a peptide derived from the C-terminus of human HDAC9. | |
RUO | |
9734 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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