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HDAC9 Mouse anti-Human, Clone: OTI2A7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526732

Catalog No. PIMA526732


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Description

Description

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.
Specifications

Specifications

HDAC9
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9UKV0
Histone deacetylase 9 (EC:3.5.1.98); HD9; Histone deacetylase 7B; HD7; HD7b; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC9; HDAC7; HDAC7B; HDRP; KIAA0744; MITR
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9734
Immunohistochemistry (Paraffin), Western Blot
OTI2A7
Unconjugated
HDAC9
Liquid
HDAC9
Human recombit protein fragment corresponding to amino acids 181-460 of HDAC9 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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