HER-2/c-erbB-2/neu Ab-1 Rabbit Polyclonal Antibody, Epredia™

Recommended for Immunohistochemistry (Formalin/paraffin), Western Blotting and Immunoprecipitation, Epredia™ HER-2/c-erbB-2/neu Ab-1, Rabbit Polyclonal Antibody provides accurate, reproducible results.

Supplier:  Epredia RB103P1

Catalog No. RB103P1

Description

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Monkey, Rat and Mouse. Others not tested.

Epitope: C-terminal

Immunogen: Synthetic peptide derived from C-terminus of human HER-2/c-erbB-2 protein. This sequence is identical in rat neu protein.

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or T47D cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunoprecipitation

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: HER-2/c-erbB-2/neu Ab-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Immunogen: Synthetic peptide derived from C-terminus of human c-erbB-2/HER-2 protein. This Sequence is identical in rat neu protein.
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated

• Applications: Immunoprecipitation, Western Blot
• Concentration: 1mg/mL
• Host Species: Rabbit
• Quantity: 500 μL
• Research Discipline: Oncogenesis
• Target Species: Human, Mouse, Non-human Primate
• Isotype: IgG