HER-2/c-erbB-2/neu Ab-2 Mouse Monoclonal Antibody, Epredia™

Provide accurate, reproducible results with the Epredia™ HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody.

Supplier:  Epredia MS229P0

Catalog No. MS229P0

Description

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: 9G6.10

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: RAC311 cells transfected with SV40-neu construct, expressing human neu protein

Molecular Weight: 185kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Frozen only) Immunofluorescence
• Immunoprecipitation
• Flow Cytometry
• Inhibits Colony Formation
• Partially Inhibits Tyrosine Kinase Activity

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: HER-2/c-erbB-2/neu Ab-2
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 100 μL
• Research Discipline: Oncogenesis
• Target Species: Human
• Isotype: IgG1

• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation
• Clone: 9G6.10
• Conjugate: Unconjugated
• Immunogen: RAC311 cells transfected with SV40-neu construct, expressing human neu protein
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated