HER-2/c-erbB-2/neu Ab-8 Mouse Monoclonal Antibody, Epredia™

Recommended for Immunohistochemistry, Western Blotting and Immunoprecipitation (Native and Denatured), Epredia™ HER-2/c-erbB-2/neu Ab-8, Mouse Monoclonal Antibody provides accurate, reproducible results.

Supplier:  Epredia MS325P1ABX

Catalog No. MS325P1ABX

Description

c-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein. The c-erbB-2 protein is overexpressed in a variety of carcinomas especially those of breast and ovary.

Host Species: Mouse

Clone: e2-4001

Isotype: IgG1

Species Reactivity: Human, Mouse and Rat. Others not tested.

Epitope: Cytoplasmic domain

Immunogen: Cytoplasmic domain of recombinant human HER-2/c-erbB-2 oncoprotein

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or T47D cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry
• Western Blotting
• Immunoprecipitation (Native and Denatured)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: HER-2/c-erbB-2/neu Ab-8
• Classification: Monoclonal
• Concentration: 1mg/mL
• Host Species: Mouse
• Quantity: 100 μL
• Research Discipline: Oncogenesis
• Target Species: Human, Mouse, Rat
• Isotype: IgG1

• Applications: Immunoprecipitation
• Clone: e2-4001
• Conjugate: Unconjugated
• Immunogen: Cytoplasmic domain of recombinant human c-erbB-2/HER-2 oncoprotein
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated