Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu (Phospho-specific) Ab-18, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu (Phospho-specific) Ab-18, Mouse Monoclonal Antibody.

$297.00 - $1416.00

Specifications

Antigen HER-2/c-erbB-2/neu (Phospho-specific) Ab-18
Clone PN2A
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Format Concentrated
View More Specs

Products 8
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity & Availability  
MS1072B
View Documents
Thermo Scientific™
MS1072B
200μg/mL Biotin 1mL
Each for $1,285.00
Add to cart
 
MS1072B0
View Documents
Thermo Scientific™
MS1072B0
200μg/mL Biotin 100μL
Each for $297.00
Add to cart
 
MS1072B1
View Documents
Thermo Scientific™
MS1072B1
200μg/mL Biotin 500μL
Each for $806.50
Add to cart
 
MS1072P
View Documents
Thermo Scientific™
MS1072P
200μg/mL Unconjugated 1mL
Each for $1,076.00
Add to cart
 
MS1072P0
View Documents
Thermo Scientific™
MS1072P0
200μg/mL Unconjugated 100μL
Each for $304.00
Add to cart
 
MS1072P1
View Documents
Thermo Scientific™
MS1072P1
200μg/mL Unconjugated 500μL
Each for $710.00
Add to cart
 
MS1072P1ABX
View Documents
Thermo Scientific™
MS1072P1ABX
1mg/mL Unconjugated 100μL
Each for $721.00
Add to cart
 
MS1072PABX
View Documents
Thermo Scientific™
MS1072PABX
1mg/mL Unconjugated 200μL
Each for $1,416.00
Add to cart
 
Description

Description

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu (Phospho-specific) Ab-18, Mouse Monoclonal Antibody.

c-erbB-2 (HER-2/neu) is a 185 kDa receptor tyrosine kinase belonging to the epidermal growth factor receptor family, which also includes EGFR (HER-1), c-erbB-3 (HER-3), and c-erbB-4 (HER-4). Amplification of the HER-2 gene with overexpression of the protein occurs in 20-30% of breast cancers, and tumor progression in mammary cancer is associated with elevated levels of tyrosine-phosphorylated neu and erbB-3. Tyr1248 is the phosphorylation site that is most tightly linked to oncogenic transformation and coupling to the ras/MAP kinase signaling pathway. Cases of invasive breast carcinoma with the phosphorylated receptor have displayed aggressive clinicopathological features and adverse prognoses. Activation of HER-2 is frequent in ductal carcinoma in situ suggesting that HER-2 signaling plays a critical role in the early stages of breast tumorigenesis.

Host Species: Mouse

Clone: PN2A

Isotype: IgG1

Species Reactivity: Human and Rat. Others not tested.

Epitope: aa 1242-1255 with pTyr

Immunogen: Tyrosine-phosphorylated synthetic peptide corresponding to aa 1242-1255 [Lys-TAENPE-pY-LGLDVPV] from the C-terminus of human HER-2 protein (P-Tyr1248)

Molecular Weight: 185 kDa

Positive Control: EGF-treated SKBR-3 cells. About 5% of breast CA are positive for phospho-HER-2/c-erbB-2/neu oncoprotein.

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Not verified)
  • Flow Cytometry (Not verified)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

HER-2/c-erbB-2/neu (Phospho-specific) Ab-18
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentrated
RUO
Primary
IgG1
PN2A
Monoclonal
Murine
EGFR Family
Tyrosine-phosphorylated synthetic peptide corresponding to aa1242-1255 [Lys-TAENPE-pY-LGLDVPV] from the C-terminus of human c-erbB-2 protein (P-Tyr1248)
SDS
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit