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HERPUD1 Mouse anti-Human, Rat, Clone: OTI1A2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526301

Catalog No. PIMA526301


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Description

Description

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.
Specifications

Specifications

HERPUD1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q15011
HERP, Mif1, SUP, MMS-inducible, homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein, homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, methyl methanesulfonate (MMF)-inducible fragme
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
85430, 9709
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI1A2
Unconjugated
HERPUD1
Liquid
Herpud1
Full length human recombit protein of HERPUD1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Rat
Documents
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