Invitrogen™ HERV-FRD Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA544470

Catalog No. PIPA544470

Description

Peptide sequence: TGSPYSTNCW LCTSSSTETP GTAYPASPRE WTSIEAELHI SYRWDPNLKG Sequence homology: Human: 100%.

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM].

Specifications

• Antigen: HERV-FRD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ERVFRD-1
• Gene Alias: Endogenous retrovirus group FRD member 1; endogenous retrovirus group FRD, member 1; envelope glycoprotein syncytin-A; envelope polyprotein; envFRD; ERVFRD-1; ERVFRDE1; FLJ41944; FLJ90611; GLLL6191; Gm52; HERV-FRD; HERV-FRD provirus ancestral Env polyprotein; HERV-FRD_6p24.1 provirus ancestral Env polyprotein; HERV-W/FRD; MGC87585; SU; Surface protein; Syna; Synb; syncytin 2; syncytin a; Syncytin2; syncytin-2; TM; Transmembrane protein; UNQ6191; UNQ6191/PRO20218
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 405754
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: P60508
• Gene Symbols: ERVFRD-1
• Immunogen: Synthetic peptide directed towards the N-terminal of human HERV-FRD (aa 35-84).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov