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HES6 Monoclonal Antibody (OTI3H10), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA800749

Encompass_Preferred

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Catalog No. 50-167-8531


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Description

Description

The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
Specifications

Specifications

HES6
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q96HZ4
HES6
Full length human recombit protein of human HES6 produced in E.coli.
100 μL
Primary
Human
Antibody
IgG2a
Western Blot
OTI3H10
Unconjugated
HES6
C-HAIRY1, HES-6, bHLHb41, bHLHc23
Mouse
Affinity Chromatography
RUO
55502
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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