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HINT1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549809

Catalog No. PA549809


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Description

Description

The antibody detects endogenous levels of total HINT1 protein.

Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5 ft.-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.
Specifications

Specifications

HINT1
Polyclonal
Unconjugated
HINT1
Liquid
HINT1
Synthesized peptide derived from internal of human HINT1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P49773, P70349, P62959
adenosine 5′-monophosphoramidase, EC 3.-.-.-, histidine triad nucleotide-binding 1, PKCI-1, PKCI1
Rabbit
IgG
100 μL
-20°C
Primary
15254, 3094, 690660
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