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Tocris Bioscience HIP-A
Potent, non-competitive EAAT inhibitor
Manufacturer: Tocris Bioscience 2217/10
DescriptionPotent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 µM) rather than [3H]L-glutamate uptake (IC50 = 18 µM). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC50 values are 43 and 8 µM respectively). .
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